Tratamento de Onicomicose por Terapia Fotodinâmica
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Abstract
Photodynamic therapy (PDT) is a technique that uses a light-emitting device and a photosensitizing chemical agent (PS) to treat diseases caused by microorganisms, such as fungi, bacteria and viruses. Several studies have been carried out and suggest that PDT can be an efficient alternative in the treatment of onychomycosis. Based on these data, the objective of this work was to carry out a review of the literature on onychomycosis and the response to treatment based on PDT. For this purpose, a search was carried out in the literature using the descriptors: onychomycosis, photodynamic therapy, LED, leisure, methylene blue or photosensitizer, with the time interval of 2014-2024. Studies have demonstrated the efficiency of PDT in the treatment of onychomycosis caused by different pathogens, making this an alternative to the use of antifungals. However, there are several light sources and FS evaluated for the application of therapy. Therefore, the most used light source was LED associated with methylene blue, which demonstrated considerable antifungal action in all selected articles, reducing or even eliminating the pathogen. Other light sources used were LASER (Light Amplification by Radiation Emission), both low (LBI) and high intensity (LAI), however LBI did not show satisfactory results when compared to LAI and LED. Thus, PDT is an effective method for the control and treatment of onychomycosis; however, its results depend on the degree of the pathology, the photosensitizer and the light source used.
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